Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration.

ABSTRACT: Vision impairment places a serious burden on the aging society, affecting the lives of millions of people. Many retinal diseases are of genetic origin, of which over 50% are due to mutations in cilia-associated genes. Most research on retinal degeneration has focused on the ciliated photoreceptor cells of the retina. However, the contribution of primary cilia in other ocular cell types has largely been ignored. The retinal pigment epithelium (RPE) is a monolayer epithelium at the back of the eye intricately associated with photoreceptors and essential for visual function. It is already known that primary cilia in the RPE are critical for its development and maturation; however, it remains unclear whether this affects RPE function and retinal tissue homeostasis. We generated a conditional k

SUBMITTER: Kretschmer V 

PROVIDER: S-EPMC10721183 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature