Arabidopsis eIF4E1 protects the translational machinery during TuMV infection and restricts virus accumulation.

ABSTRACT: Successful subversion of translation initiation factors eIF4E determines the infection success of potyviruses, the largest group of viruses affecting plants. In the natural variability of many plant species, resistance to potyvirus infection is provided by polymorphisms at eIF4E that renders them inadequate for virus hijacking but still functional in translation initiation. In crops where such natural resistance alleles are limited, the genetic inactivation of eIF4E has been proposed for the engineering of potyvirus resistance. However, recent findings indicate that knockout eIF4E alleles may be deleterious for plant health and could jeopardize resistance efficiency in comparison to functional resistance proteins. Here, we explored the cause of these adverse effects by studying the role of

SUBMITTER: Zafirov D 

PROVIDER: S-EPMC10721207 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature