GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle.

ABSTRACT: Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle-specific expression of growth arrest and DNA damage inducible α (GADD45A), a signaling protein whose expression in skeletal muscle rises during aging and a wide range of illnesses and injuries. We found that GADD45A induced several cellular changes that are characteristic of skeletal muscle atrophy, including a reduction in skeletal muscle mitochondria and oxidative capacity, selective atrophy of glycolytic muscle fibers, and paradoxical expression of oxidative myosin heavy chains despite mitochondrial loss. These cellular changes were at least partly mediated

SUBMITTER: Marcotte GR 

PROVIDER: S-EPMC10721312 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature