Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation.

ABSTRACT: Accumulation of lipid-laden macrophages within the arterial neointima is a critical step in atherosclerotic plaque formation. Here, we show that reduced levels of the cellular plasticity factor ZEB1 in macrophages increase atherosclerotic plaque formation and the chance of cardiovascular events. Compared to control counterparts (Zeb1^WT/Apoe^KO), male mice with Zeb1 ablation in their myeloid cells (Zeb1^∆M/Apoe^KO) have larger atherosclerotic plaques and higher lipid accumulation in their macrophages due to delayed lipid traffic and deficient cholesterol efflux. Zeb1^∆M/Apoe^KO mice display more pronounced systemic metabolic alterations than Zeb1^WT/Apoe^KO mice, with higher serum levels of low-density lipoprot

SUBMITTER: Martinez-Campanario MC 

PROVIDER: S-EPMC10721632 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature