Time spent above optimal cerebral perfusion pressure is not associated with failure to improve in outcome in traumatic brain injury.

ABSTRACT:

Background

Optimal cerebral perfusion pressure (CPPopt) has emerged as a promising personalized medicine approach to the management of moderate-to-severe traumatic brain injury (TBI). Though literature demonstrating its association with poor outcomes exists, there is yet to be work done on its association with outcome transition due to a lack of serial outcome data analysis. In this study we investigate the association between various metrics of CPPopt and failure to improve in outcome over time.

Methods

CPPopt was derived using three different cerebrovascular reactivity indices; the pressure reactivity index (PRx), the pulse amplitude index (PAx), and the RAC index. For each index, % times spent with cerebral perfusion pressure (CPP) above and below its CPPopt and upper and

SUBMITTER: Stein KY 

PROVIDER: S-EPMC10721751 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature