Filtering property of myelinated internode can change neural information representability and might trigger a compensatory action during demyelination.

ABSTRACT: In this paper, for the first time, we showed that an Internode Segment (INS) of a myelinated axon acts as a lowpass filter, and its filter characteristics depend on the number of myelin turns. Consequently, we showed how the representability of a neural signal could be altered with myelin loss in pathological conditions involving demyelinating diseases. Contrary to the traditionally held viewpoint that myelin geometry of an INS is optimised for maximising Conduction Velocity (CV) of Action Potential (AP), our theory provides an alternative viewpoint that myelin geometry of an INS is optimised for maximizing representability of the stimuli a fibre is meant to carry. Subsequently, we show that this new viewpoint could explain hitherto unexplained experimentally observed phenomena such as, sh

SUBMITTER: Das S 

PROVIDER: S-EPMC10721845 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature