Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats.

ABSTRACT: Alcohol Use Disorder (AUD) adversely affects the lives of millions of people, but still lacks effective treatment options. Recent advancements in psychedelic research suggest psilocybin to be potentially efficacious for AUD. However, major knowledge gaps remain regarding (1) psilocybin's general mode of action and (2) AUD-specific alterations of responsivity to psilocybin treatment in the brain that are crucial for treatment development. Here, we conducted a randomized, placebo-controlled crossover pharmaco-fMRI study on psilocybin effects using a translational approach with healthy rats and a rat model of alcohol relapse. Psilocybin effects were quantified with resting-state functional connectivity using data-driven whole-brain global brain connectivity, network-based statistics, graph th

SUBMITTER: Reinwald JR 

PROVIDER: S-EPMC10721862 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature