Maternal antibiotic exposure enhances ILC2 activation in neonates via downregulation of IFN1 signaling.

ABSTRACT: Microbiota have an important function in shaping and priming neonatal immunity, although the cellular and molecular mechanisms underlying these effects remain obscure. Here we report that prenatal antibiotic exposure causes significant elevation of group 2 innate lymphoid cells (ILC2s) in neonatal lungs, in both cell numbers and functionality. Downregulation of type 1 interferon signaling in ILC2s due to diminished production of microbiota-derived butyrate represents the underlying mechanism. Mice lacking butyrate receptor GPR41 (Gpr41^-/-) or type 1 interferon receptor IFNAR1 (Ifnar1^-/-) recapitulate the phenotype of neonatal ILC2s upon maternal antibiotic exposure. Furthermore, prenatal antibiotic exposure induces epigenetic changes in ILC2s and has a long-lasting de

SUBMITTER: Xu H 

PROVIDER: S-EPMC10721923 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature