Multisequence MRI-based radiomics analysis for early prediction of the risk of T790M resistance in new brain metastases.

ABSTRACT:

Background

Predicting whether T790M emerges early is crucial to the adjustment of targeted drugs for non-small cell lung cancer (NSCLC) patients. This study aimed to evaluate the risk of T790M resistance in progressive new brain metastases (BMs) based on multisequence magnetic resonance imaging (MRI) radiomics.

Methods

This retrospective study included 405 consecutive patients (training cohort: 294 patients; testing cohort: 111 patients) with proven NSCLC with disease progression of new BM. The radiomics features were separately extracted from T2-weighted imaging (T2WI), T2 fluid-attenuated inversion recovery (T2-FLAIR), diffusion-weighted imaging (DWI), and contrast-enhanced T1-weighted imaging (T1-CE) sequence of baseline MRI. Then, we calculated radiomics scores (rad-scor

SUBMITTER: Lv X 

PROVIDER: S-EPMC10722019 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature