Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia.

ABSTRACT:

Background

Dementia is a debilitating neurological disease affecting millions of people worldwide. The exact mechanisms underlying the initiation and progression of the disease remain to be fully defined. There is an increasing body of evidence for the role of immune dysregulation in the pathogenesis of dementia, where blood-borne autoimmune antibodies have been studied as potential markers associated with pathological mechanisms of dementia.

Methods

This study included plasma from 50 cognitively normal individuals, 55 subjects with MCI (mild cognitive impairment), and 22 subjects with dementia. Autoantibody profiling for more than 1,600 antigens was performed using a high throughput microarray platform to identify differentially expressed autoantibodies in MCI and dementia.

SUBMITTER: Ehtewish H 

PROVIDER: S-EPMC10722091 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature