Translating single-neuron axonal reconstructions into meso-scale connectivity statistics in the mouse somatosensory thalamus.

ABSTRACT: Characterizing the connectomic and morphological diversity of thalamic neurons is key for better understanding how the thalamus relays sensory inputs to the cortex. The recent public release of complete single-neuron morphological reconstructions enables the analysis of previously inaccessible connectivity patterns from individual neurons. Here we focus on the Ventral Posteromedial (VPM) nucleus and characterize the full diversity of 257 VPM neurons, obtained by combining data from the MouseLight and Braintell projects. Neurons were clustered according to their most dominantly targeted cortical area and further subdivided by their jointly targeted areas. We obtained a 2D embedding of morphological diversity using the dissimilarity between all pairs of axonal trees. The curved shape of the

SUBMITTER: Timonidis N 

PROVIDER: S-EPMC10722239 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature