Association between gut microbiota and NAFLD/NASH: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Recent studies have suggested a relationship between gut microbiota and non-alcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH). However, the nature and direction of this potential causal relationship are still unclear. This study used two-sample Mendelian randomization (MR) to clarify the potential causal links.

Methods

Summary-level Genome-Wide Association Studies (GWAS) statistical data for gut microbiota and NAFLD/NASH were obtained from MiBioGen and FinnGen respectively. The MR analyses were performed mainly using the inverse-variance weighted (IVW) method, with sensitivity analyses conducted to verify the robustness. Additionally, reverse MR analyses were performed to examine any potential reverse causal associations.

Results

Our

SUBMITTER: Zhai Q 

PROVIDER: S-EPMC10722258 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature