Altered cortical and subcortical morphometric features and asymmetries in the subjective cognitive decline and mild cognitive impairment.

ABSTRACT:

Introduction

This study aimed to evaluate morphological changes in cortical and subcortical regions and their asymmetrical differences in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). These morphological changes may provide valuable insights into the early diagnosis and treatment of Alzheimer's disease (AD).

Methods

We conducted structural MRI scans on a cohort comprising 62 SCD patients, 97 MCI patients, and 70 age-, sex-, and years of education-matched healthy controls (HC). Using Freesurfer, we quantified surface area, thickness, the local gyrification index (LGI) of cortical regions, and the volume of subcortical nuclei. Asymmetry measures were also calculated. Additionally, we explored the correlation between morphological chan

SUBMITTER: Yang J 

PROVIDER: S-EPMC10722314 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature