Multifunctional effect of flavonoids from Millettia brandisiana against Alzheimer's disease pathogenesis.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and neuronal death. Fifteen flavonoids from Millettia brandisiana were evaluated for the multifunctional effect against AD pathogenesis, including butyrylcholine esterase (BuChE) inhibition, anti-amyloid beta (Aβ) aggregation and neuroprotection against hydrogen peroxide (H₂O₂) toxicity in differentiated human neuroblastoma SH-SY5Y cell. To understand the mechanism and structure-activity relationship, binding interactions between flavonoids and the BuChE and Aβ were investigated in silico. Furthermore, drug-likeness properties and ADMET parameters were evaluated in silico using SwissADME and pKCSM tools. All flavonoids exhibit a good drug-likeness profil

SUBMITTER: Arsito PN 

PROVIDER: S-EPMC10722324 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature