Elevated mucus interleukin-17A levels are associated with increased prior sinus surgery for chronic rhinosinusitis.

ABSTRACT:

Background

Recent advances in molecular biology have enabled the identification of potential inflammatory endotypes of chronic rhinosinusitis (CRS), with prior work suggesting differential short-term surgical outcome trajectories based on cytokine signatures. However, there is a paucity of data assessing long-term treatment failure and need for revision surgery based on inflammatory biomarkers.

Methods

Retrospective analysis of prospectively collected cross-sectional data from 231 patients electing surgical therapy for CRS. Intraoperative mucus specimens were quantitatively sampled for inflammatory cytokines using a multiplex flow cytometric bead assay. Univariate Spearman correlations between cytokine levels and prior number of surgeries were assessed. A stepwise adjusted m

SUBMITTER: Chapurin N 

PROVIDER: S-EPMC10722354 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature