Atezolizumab in Combination With Carboplatin and Survival Outcomes in Patients With Metastatic Triple-Negative Breast Cancer: The TBCRC 043 Phase 2 Randomized Clinical Trial.

ABSTRACT:

Importance

Agents targeting programmed death ligand 1 (PD-L1) have demonstrated efficacy in triple-negative breast cancer (TNBC) when combined with chemotherapy and are now the standard of care in patients with PD-L1-positive metastatic disease. In contrast to microtubule-targeting agents, the effect of combining platinum compounds with programmed cell death 1 (PD-1)/PD-L1 immunotherapy has not been extensively determined.

Objective

To evaluate the efficacy of atezolizumab with carboplatin in patients with metastatic TNBC.

Design, setting, and participants

This phase 2 randomized clinical trial was conducted in 6 centers from August 2017 to June 2021.

Interventions

Patients with metastatic TNBC were randomized to receive carboplatin area under the curve (AUC) 6

SUBMITTER: Lehmann BD 

PROVIDER: S-EPMC10722391 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature