A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation.

ABSTRACT:

Background

The coordinated transcriptional regulation of activated T-cells is based on a complex dynamic behavior of signaling networks. Given an external stimulus, T-cell gene expression is characterized by impulse and sustained patterns over the course. Here, we analyze the temporal pattern of activation across different T-cell populations to develop consensus gene signatures for T-cell activation.

Results

Here, we identify and verify general biomarker signatures robustly evaluating T-cell activation in a time-resolved manner. We identify time-resolved gene expression profiles comprising 521 genes of up to 10 disjunct time points during activation and different polarization conditions. The gene signatures include central transcriptional regulators of T-cell activation, rep

SUBMITTER: Rade M 

PROVIDER: S-EPMC10722659 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature