The inter-link of ageing, cancer and immunity: findings from real-world retrospective study.

ABSTRACT:

Background

Although the concept of declined immune function associated with cancer has been accepted extensively, real-world clinical studies focusing on analysis of the peripheral blood immune changes underlying ageing, immunity and cancer are scarce.

Methods

In this case-control study, we retrospectively analysed 1375 cancer patients and enrolled 275 age and gender matched healthy individuals. Flow cytometry was conducted to assess the immune changes. Further analysis was examined by SPSS 17.0 and GraphPad Prism 9 software.

Results

Cancer patients showed obviously decreased CD3⁺ T, CD3⁺CD4⁺ Th, CD3⁺CD8⁺ CTL, CD19⁺ B, CD16⁺CD56⁺ NK cell counts and lower percentage of PD-1 (program

SUBMITTER: Fu X 

PROVIDER: S-EPMC10722682 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature