Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is widely prevalent worldwide, and respiratory tract infections (RTIs) have become the primary cause of death for T2DM patients who develop concurrent infections. Among these, Pseudomonas aeruginosa infection has been found to exhibit a high mortality rate and poor prognosis and is frequently observed in bacterial infections that are concurrent with COVID-19. Studies have suggested that acarbose can be used to treat T2DM and reduce inflammation. Our objective was to explore the effect of acarbose on P. aeruginosa RTI in T2DM individuals and elucidate its underlying mechanism.

Methods

High-fat diet (HFD) induction and P. aeruginosa inhalation were used to establish a RTI model in T2DM mice. The effect and mechanism of acarbose admini

SUBMITTER: Liu L 

PROVIDER: S-EPMC10722695 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature