Microfluidic device for enhancement and analysis of osteoblast differentiation in three-dimensional cell cultures.

ABSTRACT: Three-dimensional (3D) cell cultures are to date the gold standard in biomedical research fields due to their enhanced biological functions compared to conventional two-dimensional (2D) cultures. 3D cell spheroids, as well as organoids, are better suited to replicate tissue functions, which enables their use both as in vitro models for basic research and toxicology, as well as building blocks used in tissue/organ biofabrication approaches. Culturing 3D spheroids from bone-derived cells is an emerging technology for both disease modelling and drug screening applications. Bone tissue models are mainly limited by the implementation of sophisticated devices and procedures that can foster a tissue-specific 3D cell microenvironment along with a dynamic cultivation regime. In this study, we conse

SUBMITTER: Killinger M 

PROVIDER: S-EPMC10722696 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature