The dual pro-inflammatory and bone-protective role of calcitonin gene-related peptide alpha in age-related osteoarthritis.

ABSTRACT:

Background

The vasoactive neuropeptide calcitonin gene-related peptide alpha (αCGRP) enhances nociception in primary knee osteoarthritis (OA) and has been shown to disrupt cartilage and joint integrity in experimental rheumatoid arthritis (RA). Little is known about how αCGRP may alter articular structures in primary OA. We investigated whether αCGRP modulates local inflammation and concomitant cartilage and bone changes in a murine model of age-dependent OA.

Methods

Sixteen- to 18-month-old αCGRP-deficient mice (αCGRP^-/-_aged) were compared to, first, age-matched wild type (WT_aged) and, second, young 4- to 5-month-old non-OA αCGRP-deficient (αCGRP^-/-_CTRL) and non-OA WT animals (WT_CTRL). αCGRP levels were measu

SUBMITTER: Hildebrandt A 

PROVIDER: S-EPMC10722726 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature