Mitochondrial DNA copy number variation across three generations: a possible biomarker for assessing perinatal outcomes.

ABSTRACT:

Background

Mitochondria have their own circular multi-copy genome (mtDNA), and abnormalities in the copy number are implicated in mitochondrial dysfunction, which contributes to a variety of aging-related pathologies. However, not much is known about the genetic correlation of mtDNA copy number across multiple generations and its physiological significance.

Methods

We measured the mtDNA copy number in cord blood or peripheral blood from 149 three-generation families, specifically the newborns, parents, and grandparents, of 149 families, totaling 1041 individuals. All of the biological specimens and information were provided by the Tohoku Medical Megabank Project in Japan. We also analyzed their maternal factors during pregnancy and neonatal outcomes.

Results

While the

SUBMITTER: Fukunaga H 

PROVIDER: S-EPMC10722810 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature