Sodium salicylate ameliorates exercise-induced muscle damage in mice by inhibiting NF-kB signaling.

ABSTRACT:

Background

Eccentric muscle contraction can cause muscle damage, which reduces the efficiency of exercise. Previous evidence suggested that Sodium salicylate (SS) could improve the repair of aged muscle. This study intends to investigate whether SS can impact skeletal muscle damage caused by eccentric exercise.

Methods

Eccentric treadmill exercise was performed to induce muscle damage in mice. Plasma levels of muscle damage markers were estimated. RT-qPCR was employed for detecting mRNA levels of proinflammatory mediators in murine gastrocnemius muscle. Immunofluorescence staining of laminin/DAPI was utilized for quantifying centrally nucleated myofibers in the gastrocnemius muscle. Western blotting was implemented to examine protein levels of mitsugumin 53 (MG53), matrix me

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10722820 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature