IL20RB signaling enhances stemness and chemotherapy resistance in pancreatic cancer.

ABSTRACT:

Objective

Pancreatic cancer is an aggressive malignancy with high mortality, and cancer cell stemness and related drug resistance are considered important contributors to its poor prognosis. The objective of this study was to identify regulatory targets associated with the maintenance of pancreatic cancer stemness.

Materials and methods

Pancreatic tumor samples were collected from patients at Sun Yat-sen University Cancer Center, followed by immunofluorescence analysis. Pancreatic cancer cell lines with Interleukin-20 receptor subunit beta (IL20RB) overexpression and knockdown were established, and clonal formation, spheroid formation and side population cell analysis were conducted. The effects of IL20RB knockdown on the tumor-forming ability of pancreatic cancer cells and

SUBMITTER: Li XH 

PROVIDER: S-EPMC10722837 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature