The Good and the Bad of SHROOM3 in Kidney Development and Disease: A Narrative Review.

ABSTRACT:

Purpose of review

Multiple large-scale genome-wide association meta-analyses studies have reliably identified an association between genetic variants within the SHROOM3 gene and chronic kidney disease. This association extends to alterations in known markers of kidney disease including baseline estimated glomerular filtration rate, urinary albumin-to-creatinine ratio, and blood urea nitrogen. Yet, an understanding of the molecular mechanisms behind the association of SHROOM3 and kidney disease remains poorly communicated. We conducted a narrative review to summarize the current state of literature regarding the genetic and molecular relationships between SHROOM3 and kidney development and disease.

Sources of information

PubMed, PubMed Central, SCOPUS, and Web of Scien

SUBMITTER: Paul A 

PROVIDER: S-EPMC10722951 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature