Exploring the anti-aging effects of fisetin in telomerase-deficient progeria mouse model.

ABSTRACT: Aging is a natural and complex process characterized by the gradual deterioration of tissue and physiological functions in the organism over time. Cell senescence, a hallmark of aging, refers to the permanent and irreversible cell cycle arrest of proliferating cells triggered by endogenous stimuli or environmental stresses. Eliminating senescent cells has been shown to extend the healthy lifespan. In this study, we established a progeria mouse model with telomerase deficiency and confirmed the presence of shortened telomere length and increased expression of aging markers p16^INK4a and p21^CIP1 in the organ tissues of G3 Tert^-/- mice. We identified fisetin as a potent senolytic drug capable of reversing premature aging signs in telomerase

SUBMITTER: Zhao R 

PROVIDER: S-EPMC10722989 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature