Time perception reflects individual differences in motor and non-motor symptoms of Parkinson's disease.

ABSTRACT: Decreasing dopaminergic function is at the core of Parkinson's disease (PD) motor symptoms and changes in dopaminergic action are associated with many comorbid non-motor symptoms in PD. Notably, dopaminergic signaling in the striatum has been shown to play a critical role in the perception of time. We hypothesize that patients with PD perceive time differently and in accordance with their specific comorbid non-motor symptoms and clinical state. This means that individual differences in clinical symptoms may be reflected in individual differences in timing behavior. To test this hypothesis, we recruited patients with PD and compared individual differences in patients' clinical state with their ability to judge intervals of time ranging from 500 ms to 1100 ms while on and off their prescribe

SUBMITTER: DiMarco EK 

PROVIDER: S-EPMC10723042 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature