An interaction network approach predicts protein cage architectures in bionanotechnology.

ABSTRACT: Protein nanoparticles play pivotal roles in many areas of bionanotechnology, including drug delivery, vaccination, and diagnostics. These technologies require control over the distinct particle morphologies that protein nanocontainers can adopt during self-assembly from their constituent protein components. The geometric construction principle of virus-derived protein cages is by now fairly well understood by analogy to viral protein shells in terms of Caspar and Klug's quasi-equivalence principle. However, many artificial, or genetically modified, protein containers exhibit varying degrees of quasi-equivalence in the interactions between identical protein subunits. They can also contain a subset of protein subunits that do not participate in interactions with other assembly units, called

SUBMITTER: Fatehi F 

PROVIDER: S-EPMC10723117 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature