Static and dynamic functional connectivity combined with the triple network model in amnestic mild cognitive impairment and Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) are characterized by abnormal functional connectivity (FC) of default-mode network (DMN), salience network (SN), and central executive network (CEN). Static FC (sFC) and dynamic FC (dFC) combined with triple network model can better study the dynamic and static changes of brain networks, and improve its potential diagnostic value in the diagnosis of AD spectrum disorders.

Methods

Differences in sFC values and dFC variability patterns among the three brain networks of the three groups (53 AD patients, 40 aMCI patients, and 40 NCs) were computed by ANOVA using Gaussian Random Field theory (GRF) correction. The correlation between FC values (sFC values and dFC variability) in the three networks an

SUBMITTER: Feng Q 

PROVIDER: S-EPMC10723161 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature