Genetic polymorphisms associated with sepsis incidence, severity, and outcomes among neonates: A mini-review.

ABSTRACT: Genetic variation remains a topic of great interest due to its potential as a risk factor for various diseases. Interactions between genes contribute to diverse phenotypes in response to factors such as infection. The impact of genetic background on susceptibility and clinical outcomes, particularly in neonatal sepsis, has gained recognition. The variability in sepsis susceptibility and outcomes can be attributed to the genetic diversity in coding regions and regulatory elements of genes related to innate immune response. Recent advances in genomics and technology have shed light on genetic polymorphisms among humans, often represented by single-nucleotide polymorphisms (SNPs). These SNPs encode proteins crucial for recognizing and responding to pathogenic bacteria, including Toll-like rec

SUBMITTER: Darnifayanti D 

PROVIDER: S-EPMC10723165 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature