Establishment and Characterization of a TP53-Mutated Eyelid Sebaceous Carcinoma Cell Line.

ABSTRACT:

Purpose

Eyelid sebaceous carcinoma (SeC) is the third most frequent eyelid malignancy worldwide and is relatively prevalent in Asian patients. An eyelid SeC cell line model is necessary for experimental research to explore the etiology and pathogenesis of eyelid SeC. This study established and characterized an eyelid SeC cell line with a TP53 mutation that might be useful for analyzing potential treatment options for eyelid SeC.

Methods

The eyelid SeC cell line SHNPH-SeC was obtained from a patient with eyelid SeC at Shanghai Ninth People's Hospital (SHNPH), Shanghai JiaoTong University School of Medicine. Immunofluorescence staining was employed to detect the origination and proliferation activity. Short tandem repeat (STR) profiling was performed for verification. Chromoso

SUBMITTER: Gu X 

PROVIDER: S-EPMC10723222 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature