Association between neurodevelopmental impairments and motor function in Duchenne muscular dystrophy.

ABSTRACT:

Objective

We explored various prognostic factors of motor outcomes in corticosteroid-naive boys with Duchenne Muscular Dystrophy (DMD).

Methods

The associations between parent-reported neurodevelopmental concerns (speech delay, speech and language difficulties (SLD), and learning difficulties), DMD mutation location, and motor outcomes (6-minute walk distance (6MWD), North Star Ambulatory Assessment (NSAA) total score, 10-meter walk/run velocity, and rise from floor velocity) were studied in 196 corticosteroid-naive boys from ages 4 to less than 8 years.

Results

Participants with SLD walked 25.8 fewer meters in 6 minutes than those without SLD (p = 0.005) but did not demonstrate statistical differences in NSAA total score, 10-meter walk/run velocity, and rise from flo

SUBMITTER: Thangarajh M 

PROVIDER: S-EPMC10723228 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature