Brain olfactory-related atrophy in isolated rapid eye movement sleep behavior disorder.

ABSTRACT:

Objective

To investigate structural and functional connectivity changes in brain olfactory-related structures in a longitudinal prospective cohort of isolated REM sleep behavior disorder (iRBD) and their clinical correlations, longitudinal evolution, and predictive values for phenoconversion to overt synucleinopathies, especially Lewy body diseases.

Methods

The cohort included polysomnography-confirmed iRBD patients and controls. Participants underwent baseline assessments including olfactory tests, neuropsychological evaluations, the Movement Disorders Society-Unified Parkinson's Disease Rating Scale, 3T brain MRI, and ¹⁸ F-FP-CIT PET scans. Voxel-based morphometry (VBM) was performed to identify regions of atrophy in iRBD, and volumes of relevant olfactory-relat

SUBMITTER: Woo KA 

PROVIDER: S-EPMC10723229 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature