Dynamic causal modeling of reorganization of memory and language networks in temporal lobe epilepsy.

ABSTRACT:

Objective

To evaluate the alterations of language and memory functions using dynamic causal modeling, in order to identify the epileptogenic hemisphere in temporal lobe epilepsy (TLE).

Methods

Twenty-two patients with left TLE and 13 patients with right TLE underwent functional magnetic resonance imaging (fMRI) during four memory and four language mapping tasks. Dynamic causal modeling (DCM) was employed on fMRI data to examine effective directional connectivity in memory and language networks and the alterations in people with TLE compared to healthy individuals.

Results

DCM analysis suggested that TLE can influence the memory network more widely compared to the language network. For memory mapping, it demonstrated overall hyperconnectivity from the left hemisphere t

SUBMITTER: Fallahi A 

PROVIDER: S-EPMC10723230 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature