Heavy macrophage infiltration identified by optical coherence tomography relates to plaque rupture.

ABSTRACT:

Objective

Risk stratification plays a critical role in patients with asymptomatic carotid atherosclerotic stenosis. Heavy macrophage infiltration (HMC) is an important factor of plaque destabilization. However, in vivo imaging technologies and screening criteria for HMC remain limited. We aimed to (i) introduce algorithms for in vivo detection of macrophage infiltrations using optical coherence tomography (OCT) and (ii) to investigate the threshold of HMC and its association with plaque vulnerability.

Methods

Ex vivo OCT images were co-registered with histopathology in 282 cross-sectional pairs from 19 carotid endarterectomy specimens. Of these, 197 randomly selected pairs were employed to define the parameters, and the remaining 85 pairs were used to evaluate the accuracy o

SUBMITTER: Shi X 

PROVIDER: S-EPMC10723231 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature