Longitudinal serum neurofilament light kinetics in post-anoxic encephalopathy.
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ABSTRACT:
SUBMITTER: Disanto G
PROVIDER: S-EPMC10723239 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
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Longitudinal serum neurofilament light kinetics in post-anoxic encephalopathy.
Disanto Giulio G Villa Michele M Maleska Maceski Aleksandra A Prosperetti Chiara C Gobbi Claudio C Kuhle Jens J Cassina Tiziano T Agazzi Pamela P
Annals of clinical and translational neurology 20230925 12
Serum neurofilament light (sNfL) is a promising marker of outcome after cardiac arrest, but its kinetics are unclear. We prospectively measured sNfL concentrations in 62 patients at 0, 1, 3, 5, 7 and 10 days after cardiac arrest. Survivors and non-survivors had similar sNfL at admission (14.2 [8.6-21.9] vs. 22.5 [14.2-46.9] pg/mL) but largely different at 24 h (16.4 [10.2-293] vs. 464.3 [151.8-1658.2], respectively). The AUC for sNfL concentrations predicting death was above 0.95 from Day 1 to 1 ...[more]
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