Enrichment of hard sweeps on the X chromosome compared to autosomes in six Drosophila species.

ABSTRACT: The X chromosome, being hemizygous in males, is exposed one third of the time increasing the visibility of new mutations to natural selection, potentially leading to different evolutionary dynamics than autosomes. Recently, we found an enrichment of hard selective sweeps over soft selective sweeps on the X chromosome relative to the autosomes in a North American population of Drosophila melanogaster. To understand whether this enrichment is a universal feature of evolution on the X chromosome, we analyze diversity patterns across six commonly studied Drosophila species. We find an increased proportion of regions with steep reductions in diversity and elevated homozygosity on the X chromosome compared to autosomes. To assess if these signatures are consistent with positive sel

SUBMITTER: Harris M 

PROVIDER: S-EPMC10723260 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature