Queuosine Salvage in Bartonella henselae Houston 1: A Unique Evolutionary Path.

ABSTRACT: Queuosine (Q) stands out as the sole tRNA modification that can be synthesized via salvage pathways. Comparative genomic analyses identified specific bacteria that showed a discrepancy between the projected Q salvage route and the predicted substrate specificities of the two identified salvage proteins: 1) the distinctive enzyme tRNA guanine-34 transglycosylase (bacterial TGT, or bTGT), responsible for inserting precursor bases into target tRNAs; and 2) Queuosine Precursor Transporter (QPTR), a transporter protein that imports Q precursors. Organisms like the facultative intracellular pathogen Bartonella henselae, which possess only bTGT and QPTR but lack predicted enzymes for converting preQ₁ to Q, would be expected to salvage the queuine (q) base, mirroring the scenario

SUBMITTER: Quaiyum S 

PROVIDER: S-EPMC10723273 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature