Impact of Δ⁹-Tetrahydrocannabinol and oxycodone co-administration on measures of antinociception, dependence, circadian activity, and reward in mice.

ABSTRACT: Oxycodone is commonly prescribed for moderate to severe pain disorders. While efficacious, long-term use can result in tolerance, physical dependence, and the development of opioid use disorder. Cannabis and its derivatives such as Δ⁹-Tetrahydrocannabinol (Δ⁹-THC) have been reported to enhance oxycodone analgesia in animal models and in humans. However, it remains unclear if Δ⁹-THC may facilitate unwanted aspects of oxycodone intake, such as tolerance, dependence, and reward at analgesic doses. This study sought to evaluate the impact of co-administration of Δ⁹-THC and oxycodone across behavioral measures related to antinociception, dependence, circadian activity, and reward in both male and female mice. Oxycodone and Δ⁹-THC produced d

SUBMITTER: Slivicki RA 

PROVIDER: S-EPMC10723318 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature