The Effects of Preeclamptic Milieu on Cord Blood Derived Endothelial Colony-Forming Cells.

ABSTRACT: Preeclampsia is one of the leading causes of infant and maternal mortality worldwide. Many infants born from preeclamptic pregnancies are born prematurely with higher risk of developing cardiovascular later in their life. A key mechanism by which these complications occur is through stress-induced dysfunction of endothelial progenitor cells (EPCs), including endothelial colony-forming cells (ECFCs). To gain insight into this, cord blood derived ECFCs isolated from preeclamptic pregnancies (PRECs) were analyzed and compared to their healthy counterparts. While PRECs preserve key endothelial markers, they upregulate several markers associated with oxidative stress and inflammatory response. Compared to ECFCs, PRECs also exhibit lower migratory behaviors and impaired angiogenic potential. Int

SUBMITTER: Hall E 

PROVIDER: S-EPMC10723349 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature