Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry.

ABSTRACT: Histone deacetylase inhibitors (HDIs) modulate β cell function in preclinical models of diabetes; however, the mechanisms underlying these beneficial effects have not been determined. In this study, we investigated the impact of the HDI sodium butyrate (NaB) on β cell function and calcium (Ca²⁺) signaling using ex vivo and in vitro models of diabetes. Our results show that NaB significantly improved glucose-stimulated insulin secretion in islets from human organ donors with type 2 diabetes and in cytokine-treated INS-1 β cells. Consistently, NaB partially rescued glucose-stimulated Ca²⁺ oscillations in mouse islets treated with proinflammatory cytokines. Because the oscillatory phenotype of Ca²⁺ in the β cell is governed by changes in endoplasmic reticulum

SUBMITTER: Lee CC 

PROVIDER: S-EPMC10723426 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature