MLL3/MLL4 enzymatic activity shapes DNA replication timing.

ABSTRACT: Mammalian genomes are replicated in a precise order during S phase, which is cell-type-specific^1-3 and correlates with local transcriptional activity^2,4-8, chromatin modifications⁹ and chromatin architecture^1,10,11,12. However, the causal relationships between these features and the key regulators of DNA replication timing (RT) are largely unknown. Here, machine learning was applied to quantify chromatin features, including epigenetic marks, histone variants and chromatin architectural factors, best predicting local RT under steady-state and RT changes during early embryonic stem (ES) cell differentiation. About one-third of genome exhibited RT changes during the differentiation. Combined, chromatin features predicted steady-state RT and RT chang

SUBMITTER: Gokbuget D 

PROVIDER: S-EPMC10723431 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature