Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse Models.

ABSTRACT: The "innate-like" T cell compartment, known as T_inn, represents a diverse group of T cells that straddle the boundary between innate and adaptive immunity, having the ability to mount rapid responses following activation. In mice, this ability is acquired during thymic development. We explored the transcriptional landscape of T_inn compared to conventional T cells (T_conv) in the human thymus and blood using single cell RNA sequencing and flow cytometry. We reveal that in human blood, the majority of T_inn cells, including iNKT, MAIT, and Vδ2⁺Vγ9⁺ T cells, share an effector program characterized by the expression of unique chemokine and cytokine receptors, and cytotoxic molecules. This program is driven by specific transcriptio

SUBMITTER: Loh L 

PROVIDER: S-EPMC10723458 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature