Adhesome Receptor Clustering is Accompanied by the Colocalization of the Associated Genes in the Cell Nucleus.

ABSTRACT: Proteins on the cell membrane cluster to respond to extracellular signals; for example, adhesion proteins cluster to enhance extracellular matrix sensing; or T-cell receptors cluster to enhance antigen sensing. Importantly, the maturation of such receptor clusters requires transcriptional control to adapt and reinforce the extracellular signal sensing. However, it has been unclear how such efficient clustering mechanisms are encoded at the level of the genes that code for these receptor proteins. Using the adhesome as an example, we show that genes that code for adhesome receptor proteins are spatially co-localized and co-regulated within the cell nucleus. Towards this, we use Hi-C maps combined with RNA-seq data of adherent cells to map the correspondence between adhesome receptor protein

SUBMITTER: Cammarata LV 

PROVIDER: S-EPMC10723460 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature