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Atlas of nascent RNA transcripts reveals enhancer to gene linkages.

ABSTRACT: Gene transcription is controlled and modulated by regulatory regions, including enhancers and promoters. These regions are abundant in unstable, non-coding bidirectional transcription. Using nascent RNA transcription data across hundreds of human samples, we identified over 800,000 regions containing bidirectional transcription. We then identify highly correlated transcription between bidirectional and gene regions. The identified correlated pairs, a bidirectional region and a gene, are enriched for disease associated SNPs and often supported by independent 3D data. We present these resources as an SQL database which serves as a resource for future studies into gene regulation, enhancer associated RNAs, and transcription factors.

SUBMITTER: Sigauke RF

PROVIDER: S-EPMC10723487 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Atlas of nascent RNA transcripts reveals enhancer to gene linkages.

Sigauke Rutendo F RF Sanford Lynn L Maas Zachary L ZL Jones Taylor T Stanley Jacob T JT Townsend Hope A HA Allen Mary A MA Dowell Robin D RD

bioRxiv : the preprint server for biology 20231208

Gene transcription is controlled and modulated by regulatory regions, including enhancers and promoters. These regions are abundant in unstable, non-coding bidirectional transcription. Using nascent RNA transcription data across hundreds of human samples, we identified over 800,000 regions containing bidirectional transcription. We then identify highly correlated transcription between bidirectional and gene regions. The identified correlated pairs, a bidirectional region and a gene, are enriched ...[more]

PMID: 38105978

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