Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs).

ABSTRACT:

Background

A range of rare mutations involving micro-deletion or -duplication of genetic material (copy number variants (CNVs)) have been associated with high neurodevelopmental and psychiatric risk (ND-CNVs). Irritability is frequently observed in childhood neurodevelopmental conditions, yet its aetiology is largely unknown. Genetic variation may play a role, but there is a sparsity of studies investigating presentation of irritability in young people with ND-CNVs.

Aims

This study aimed to investigate whether there is a difference in irritability in young people with rare ND-CNVs compared to those without ND-CNVs, and to what extent irritability is associated with psychiatric diagnoses and cognitive ability (IQ).

Methods

Irritability and broader psychopathology was a

SUBMITTER: Hall JH 

PROVIDER: S-EPMC10723492 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature