BrainAGE Estimation: Influence of Field Strength, Voxel Size, Race, and Ethnicity.

ABSTRACT: The BrainAGE method is used to estimate biological brain age using structural neuroimaging. However, the stability of the model across different scan parameters and races/ethnicities has not been thoroughly investigated. Estimated brain age was compared within- and across- MRI field strength and across voxel sizes. Estimated brain age gap (BAG) was compared across demographically matched groups of different self-reported races and ethnicities in ADNI and IMAS cohorts. Longitudinal ComBat was used to correct for potential scanner effects. The brain age method was stable within field strength, but less stable across different field strengths. The method was stable across voxel sizes. There was a significant difference in BAG between races, but not ethnicities. Correction procedures are sugge

SUBMITTER: Dempsey DA 

PROVIDER: S-EPMC10723496 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature