Age-related Muscle Fat Infiltration in Lung Screening Participants: Impact of Smoking Cessation.

ABSTRACT:

Rationale

Skeletal muscle fat infiltration progresses with aging and is worsened among individuals with a history of cigarette smoking. Many negative impacts of smoking on muscles are likely reversible with smoking cessation.

Objectives

To determine if the progression of skeletal muscle fat infiltration with aging is altered by smoking cessation among lung cancer screening participants.

Methods

This was a secondary analysis based on the National Lung Screening Trial. Skeletal muscle attenuation in Hounsfield unit (HU) was derived from the baseline and follow-up low-dose CT scans using a previously validated artificial intelligence algorithm. Lower attenuation indicates greater fatty infiltration. Linear mixed-effects models were constructed to evaluate the association

SUBMITTER: Xu K 

PROVIDER: S-EPMC10723505 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature