Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology.

ABSTRACT:

Background

Autism and attention deficit hyperactivity disorder (ADHD) are heterogeneous neurodevelopmental conditions with complex underlying neurobiology. Despite overlapping presentation and sex-biased prevalence, autism and ADHD are rarely studied together, and sex differences are often overlooked. Normative modelling provides a unified framework for studying age-specific and sex-specific divergences in neurodivergent brain development.

Methods

Here we use normative modelling and a large, multi-site neuroimaging dataset to characterise cortical anatomy associated with autism and ADHD, benchmarked against models of typical brain development based on a sample of over 75,000 individuals. We also examined sex and age differences, relationship with autistic traits, and explore

SUBMITTER: Bedford SA 

PROVIDER: S-EPMC10723556 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature