Assessing the validity of a self-reported clinical diagnosis of schizophrenia.

ABSTRACT:

Background

Diagnoses in psychiatric research can be derived from various sources. This study assesses the validity of a self-reported clinical diagnosis of schizophrenia.

Methods

The study included 3,029 clinically ascertained participants with schizophrenia or psychotic disorders diagnosed by self-report and/or research interview and 1,453 UK Biobank participants with self-report and/or medical record diagnosis of schizophrenia or schizoaffective disorder depressed-type (SA-D). We assessed positive predictive values (PPV) of self-reported clinical diagnoses against research interview and medical record diagnoses. We compared polygenic risk scores (PRS) and phenotypes across diagnostic groups, and compared the variance explained by schizophrenia PRS to samples in the Psychia

SUBMITTER: Woolway GE 

PROVIDER: S-EPMC10723562 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature